Linzess Pros and Cons

Linzess is a prescription medication used to treat persistent constipation, also known as chronic irritable bowel syndrome (IBS), in individuals who have constipation as the primary symptom of their condition.

Linzess (linaclotide) works by enhancing chloride and water secretion in the intestines, which helps to soften stools and stimulates bowel movements.

Linzess (Linaclotide) is an agonist that triggers the guanylate cyclase 2C cell surface receptor (GC-C). The drug attaches to the epithelial cells of the intestine's mucosa. At therapeutic level, linaclotide is poorly absorbed and is untraceable in the circulatory system. When GC-C is activated, the amount of cyclic guanosine monophosphate in the body rises (cGMP). 

Linaclotide is also thought to decrease colonic sensory neuron excitability, thereby alleviating pain, and stimulate colonic motor neurons, thereby increasing smooth muscle contraction and thus promoting the digestion process.

You may need up to two weeks to notice an improvement in your symptoms. Continue to take the medication as prescribed and notify your doctor if your clinical signs do not improve after a few days.

Keep it at room temperature and away from moisture and heat to maintain its efficacy. Also, keep the tablets and the packet or canister of moisture-absorbing preservatives in their original containers.

This medication should not be given or taken by children. Linaclotide is a medication that is dangerous for young children who inadvertently swallow it.

Linzess Pros:

Linzess is a helpful drug for those who have irritable bowel syndrome with constipation (IBS-C) and is also approved by the US FDA for this indication. Its mechanism of action is well understood to relieve symptoms of constipation associated with IBS.

It is generally safe for all adults who have no known allergies. Patients may notice significant improvements in symptoms after 2 weeks of its usage. It increases the water content in the intestinal area, thereby relieving the symptoms of hard stool and constipation.

Linzess Pros and Cons

Linzess Cons:

It is a prescription product and must not be used without seeking proper advice from a doctor. Individuals having a known history of allergy must be careful about using this medicine.

This medicine is not safe for children and should be kept out of reach of children. This medicine is associated with some side effects, e.g. vomiting, diarrhea, heartburn, and abdominal pain.

Some side effects are dose-dependent and may subside after 1 week of stopping the medicine. These side effects include abdominal distention, flatulence, bloating, etc.

This drug is contraindicated in children aged less than 6 years and may put their lives in danger if used mistakenly due to the high risk of dehydration.

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