Protandim Pros and Cons, NRF1 & NRF2 Difference & Reviews

LifeVantage Corporation markets Protandim®, a dietary supplement that contains 5 plant extracts (milk thistle, bacopa, ashwagandha root, turmeric, and green tea) that presumably triggers the Nuclear factor (erythroid-derived 2)-like 2 transcription factor pathway, which is essential for the production of numerous antioxidant enzymes, such as -glutamyl cysteine synthase (GCS) (an enzyme that catalyzes the committed step in glutathione synthesis).

Nuclear factor (erythroid-derived 2)-like 2 is a leucine zipper protein transcription factor that controls the expression of antioxidant proteins that shield cells from oxidative degradation caused by trauma and infection.

Several clinical trials using Protandim® have been conducted in the last 10 years, but only 3 have been evaluated in human participants. The outcomes of those human trials were contradictory, with some suggesting that long-term administration lowered oxidative destruction and others revealing no change in oxidative destruction. Even so, there was no placebo group in research that showed oxidative damage was reduced after a month of consumption.

Due to the current controversy surrounding Protandim's effects, we'll take a look at some of the positives and negatives of the product:

Protandim Pros:

According to reported claims which are not yet evaluated by US FDA, this supplement benefits in the following way,

Persons who are at high risk of having a heart attack may benefit from taking Protandim because it has the potential to lower their blood pressure. People who take the supplement claim to be more energetic and to sleep better at night after taking it. Its antioxidant properties can help to strengthen your immune system while also promoting hormonal balance.

The supplement is characterized as a food because it is made up of organic plant extracts, according to the FDA. Take it with food daily to ensure that it is properly absorbed, just like any other vitamin or supplement. Protandim supplements have been shown to enhance cardiac health. It accomplishes this by inhibiting intimal hyperplasia on vascular walls, thereby promoting improved blood circulation.

Some people who suffer from joint pain reported significant positive changes in their health. They reported less discomfort as well as mental alertness, clarity, and increased energy. Protandim can help you lower oxidative stress by restoring a healthy balance in your body's percentage of antioxidants to free radicals.

Other illnesses may be prevented or treated with the help of the supplement. For instance, by lowering oxidative stress it may be possible to lower your risk of developing cancer in the future. It has the potential to naturally lessen the incidence of aging by boosting cell health.

Protandim Pros and Cons, NRF1 & NRF2 Difference & Reviews

Protandim Cons:

Protandim may overstate the health benefits. The Food and Drug Administration (FDA) issued a cease and desist order to LifeVantage in 2017 in response to its false advertising. There is 1.8 mg of caffeine in Protandim, making it a caffeinated product. Although it is a minuscule portion, if you are hypersensitive to caffeine, this can have negative consequences. Otherwise, other multivitamins might be a better choice for you in this situation.

People who took Protandim experienced a 4.9 percent rise in uric acid levels. Gout can be caused by uric acid, or it can worsen the condition if this has already been present. Diabetes is also linked to high levels of uric acid. When taking the supplement, some people report experiencing negative effects. They vary from stomach pains to rashes on the skin, flatulence, diarrhea, indigestion, and cramps.

If you are pregnant or nursing, you should consult with your doctor. According to the experts, there may be negative consequences for your child.

What is NRF1?

Nuclear respiratory factor 1, also abbreviated Nrf1, is a transcription factor that homodimerizes and initiates the expression of some vital cellular genes that regulate cell development as well as nuclear genes needed for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.

How NRF1 Synergizer Works?

As per claim, Protandim® NRF1 Synergizer works by boosting mitochondrial energy by supplying essential nutrients to it. As mitochondria are a powerhouse of the cells which are essential for all cellular activities so, enhancing its functions means an overall improvement in body processes.

What is NRF2?

Nuclear factor erythroid 2-related factor 2, also abbreviated as NRF2, is a transcription factor expressed by the NFE2L2 gene in mammals. As per human studies, NRF2 is a fundamental leucine zipper (bZIP) protein that regulates the expression of antioxidant proteins that defend against oxidative destruction caused by trauma and illness.

How NRF2 Synergizer Works?

As per claim, NRF2 Synergizer enhances the expression of antioxidant proteins by synergizing Nuclear factor erythroid 2-related factor and helps the body to fight against certain conditions associated with oxidative degradation, infections, inflammatory conditions, etc.

However, all these claims have yet to be evaluated by the US FDA.

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