Ozempic is a subcutaneous injection used for treatment of type 2 diabetes mellitus. Semalutide is the active ingredient of Ozempic. Semalutide is a human GLP receptor agonist. Main function of semalutide is albumin binding. Ozempic is a sterile, colorless, aqueous and clear solution. Along with active ingredient, it also have some inactive ingredients like disodium phosphate dehydrate, propylene glycol, phenol and water. The pH of Ozempic is about 7.4. pH stabilizers are also added to maintain pH of subcutaneous injection. Hydrochloric acid or sodium hydroxide are added to stabilize pH of Ozempic solution. It is available in the form of pen.
Diabetes mellitus type 2 is a condition in which patient suffer from insulin resistance with high blood sugar level. Also with less production of insulin. It show symptoms like increased thirst, increased urination, and weight loss. It normally occurs in middle or older age. It occurs due to obesity or genetics or lack of exercise. So its treatment include balanced diet and exercise along with medication. Ozempic is used as an adjunct to diet and exercise. Insulin therapy is continued with Ozempic dosing. Ozempic in type 2 diabetes mellitus cannot be used as substitute for insulin.
Ozempic is an insulin companion and works with it. Used specifically for diabetes mellitus type 2. It is a GLP-1 receptor agonist or also GLP-1 analog. Semalutide modify 26th position of lysine to enable albumin binding. Semalutide change lysine position with hydrophilic spacer and C18 fatty di-acid.
Ozempic/Semaglutide Side effects
Ozempic also have some side effects and adverse effects reported. There is a greater risk of thyroid c-cell tumor. Pancreatitis can occur. There may be complications in Diabetic retinopathy.Hypoglycemia can occur if insulin secretagogues or insulin is used concomitantly. Some clinical trials also reported about hypersensitivity reactions. Rash and allergy due to rubbing in hypersensitivity reaction. Kidney injury or failure is also involved because of its elimination route through kidney. In order to avoid these all above mentioned diseases, Ozempic should be used with great care and with proper precautions.
Ozempic is used as an adjunct to exercise and diet in patients with diabetes mellitus type 2. It is used to control blood glucose level. It is never used as a 1st line therapy for patients who have glycemic control on diet and exercise. Patients with pancreatitis cannot use Ozempic because it is also reported with pancreatitis as side or adverse effect. Ozempic cannot be used in place of insulin and also it is not recommended for patients with type 1 diabetes mellitus. Also diabetic ketoacidosis cannot be treated with Ozempic. Ozempic will not be effective in above mentioned conditions.
Starting dose of Ozempic should be 0.25mg subcutaneous which should be administer once a week for up to 4 weeks. After 4 weeks, the dose is increased up to 0.5mg per week. If still there is a need of glycemic control, then dosage is further increased up to 1 mg per week. It is the maximum recommended dose. Ozempic can be administered at any time of the selected day of week and can be administered with or without meal. If any dose of Ozempic is missed by chance, then patient should administer the missed dose within 5 days of the dose day.